Tariff threats take aim at fentanyl trafficking. Here's how the drug reaches the U.S.

President Donald Trump's plan to impose tariffs on goods from Mexico, Canada and China is partly aimed at combating the illicit flow of fentanyl into the U.S., where the opioid is blamed for some 70,000 overdose deaths annually.

Mexico agreed Monday to send 10,000 troops to the U.S.-Mexico border as part of a deal with Trump to pause the tariffs for a month — and hold off levying its own.

Neither Canada nor China has signaled major changes to tackle the flow of fentanyl into the U.S., and each has said it would retaliate for any U.S. tariffs.

What role do Mexico, Canada and China play in fentanyl reaching the U.S.? And how much can their governments do?

Where does fentanyl come from?

The ingredients in fentanyl are largely produced by companies in China and used by pharmaceutical companies to make legal painkillers. But a portion of those chemicals is purchased by the Sinaloa and Jalisco cartels in Mexico.

Cartels make the synthetic opioid in labs and then smuggle it into the U.S., largely at official land crossings in California and Arizona. The small amounts of fentanyl in any shipment — the drug is 50 times more potent than heroin — and its lack of odor, make detection and seizures extremely challenging.

Fentanyl is also made in Canada and smuggled into the U.S., but to a much lesser extent. U.S. customs agents seized 43 pounds (19.5 kilograms) of fentanyl at the Canadian border during the last fiscal year, compared with 21,100 pounds (9,570 kilograms) at the Mexican border.

Seizures of fentanyl jumped by as much as tenfold under President Joe Biden, an increase that may reflect improved detection.

What changed after Trump threatened tariffs?

Mexico announced in December the seizure of more than a ton of fentanyl pills in what it described as the largest bust of synthetic opioids in the country's history. The haul was striking because fentanyl seizures in Mexico had fallen dramatically in the first half of 2024.

Under President Claudia Sheinbaum, who took office in October, Mexico's security forces appear to be far more aggressive than they were under her predecessor. Former President Andrés Manuel López Obrador denied that fentanyl was even produced in Mexico, contradicting officials in his own administration.

To pause the tit-for-tat tariffs, Mexico agreed to immediately deploy 10,000 National Guard troops to the border to battle drug-trafficking, while the U.S. committed to do more to stop the trafficking of guns into Mexico, said Trump and Sheinbaum on social media.

Facing tariff threats, Canadian Prime Minister Justin Trudeau has highlighted his country's recent $1.3 billion investment in border enforcement, including chemical detection tools at entry ports and a new unit focused on the oversight of precursor chemicals.

Once Trump ordered the tariffs, Trudeau rebuked the move.

“We, too, are devastated by the scourge that is fentanyl,” Trudeau said at a press conference Sunday. “As neighbors, we must work collaboratively to fix this. Unfortunately, the actions taken today by the White House split us apart instead of bringing us together.”

China defended its efforts to combat fentanyl in what has been years of touch-and-go cooperation with the U.S. China doesn't have the same fentanyl crisis among its own population, and doesn't view it as a priority, said Zongyuan Zoe Liu, a senior fellow for China studies at the Council on Foreign Relations.

How much can Mexico, Canada and China do?

Combating the production and movement of illicit fentanyl is particularly challenging.

Unlike heroin and cocaine, which are produced from plants, fentanyl is made with ingredients used for legal pharmaceutical drugs, and can be made in cheap labs that can be erected relatively quickly. And despite the dangers, demand in the U.S. for the highly addictive drug remains strong.

"Even if Mexico, Canada and these other countries snap their fingers and did away with the drug trade, as long as we have that demand, there will be another country that will satisfy that demand,” said Mike Vigil, the former chief of international operations at the U.S. Drug Enforcement Agency.

Vigil said trade frictions could impede the fight. “If we don’t work together and share information, the only ones who are going to benefit from that are drug cartels,” he said.

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Bedayn is a corps member for the Associated Press/Report for America Statehouse News Initiative. Report for America is a nonprofit national service program that places journalists in local newsrooms to report on undercovered issues.